Cyrille HEBERT Pharmaceuticals Export Sales Manager Russia and CIS

MAJOR THERAPEUTIC AREAS & MEDICINES

Arthritis

Enbrel ®             (Etanercep)        Wyeth

 is a prescription medicine that can be self-injected. It is used to treat five long-term inflammatory diseases: moderate to severe rheumatoid arthritis (RA), moderate to severe plaque psoriasis, psoriatic arthritis, moderate to severe juvenile idiopathic arthritis (JIA), and ankylosing spondylitis (AS).

Central Nervous System

Atarax ®           (Hydroxyzine- Hydrochloride)       UCB

is indicated in the management of anxiety and tension as in the preparation for dental procedures and in acute emotional problems. Also used in the management of anxiety associated with organic disturbances and as adjunctive therapy in alcoholism and allergic conditions with strong emotional overlay, such as in asthma.

Atarax is useful in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses.

Atarax is also useful in the control of nausea and vomiting, excluding nausea and vomiting of pregnancy .

Deroxat ®            ( Paroxetine )       GSK

Deroxat is an antidepressant in a group of drugs called Selective Serotonin Reuptake Inhibitors (SSRIs).

Major depressive disorder

Obsessive Compulsive Desorder

Panic Disorder

Social Anxiety Disorder

Generalized Anxiety Disorder

Posttraumatic stress Disorder

Premenstrual Dysforic Disorder (controlled release formulation)

Effexor ®              (Venlafaxine)        Wyeth Pharmaceuticals

is an antidepressant in a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). Effexor affects chemicals in the brain that may become unbalanced and cause depression.

Effexor is used to treat major depressive disorder, anxiety, and panic disorder.

Exelon ® Patch   ( Rivastigmine Trandermal System)   Novartis

is a prescription medecine used to treat people with mild to moderate Alzheimer's dementia.

It is also used to treat people with mild to moderate Parkinson's disease dementia (PDD).

Persons who have been diagnosed with Parkinson's disease for at least 2 years and in whom other causes of dementia have been ruled out may have PDD if they experience trouble with the following executive function (i.e remembering things, solving problems, and planning), memory retrieval, and attention.

Migpriv ® ( Lysine Acetylsalicylate - Metoclopramide) Sanofy-Synthelabo

is indicated for the acute treatment of migraine with or without aura in adult. 

Seroplex ®       (Escitalopram)      Lundbeck  

Double (SSRIs).

Seroplex is licenced for the treatment of major depressive disorder (MDD), generalised anxiety disorder (GAD), social anxiety disorder (SAD), panic disorder (PD) and obsessive compulsive disorder (OCD)

Stilnox ®         (Zolpidem)               Sanofy-Synthelabo

is used for the short-term treatment of insomnia, as well as some brain disorders

Subutex  ®       (Buprenorphine HCI )     Schering Plough

  is indicated for the treatment of opioid dependence. 

Vasobral ®  ( Mesylate Dihydroergocryptine )  Chiesi  Pharmaceuticals

 for cerebral vascular insufficiency, especially accompanied by vertigo, tinnitus, such as cochlear and vestibular dysfunction and visually impaired people. Can be used for cerebrovascular accident, brain dysfunction, insomnia, memory deterioration, wisdom diminishes, peripheral vascular dysfunction (eg, tingling sense), such as attention deficit hyperactivity disorder.

Vogalene®       (Metopimazine)       Cephalon                       Nausea and vomiting.

Xanax®            ( Alprazolam )       Pfizer

is used for the short -term management of Anxiety Disorders, Panic Disorders.

Zomig®       (Zolmitriptan)          AstraZeneca

is indicated for the acute treatment of migraine with or without aura in adult

Cardiovascular

Kardegic ® (Aspirin Lysine )     Sanofy-Aventis 

based prevention of thrombosis and embolism, primary and secondary prevention of myocardial infarction, prevention of violations of cerebral circulation by ischemic type.

Plavix®      (Clopidogrel Bisufate)    Sanofy-Aventis

this Blood Thinner is a P2Y12 platelet inhibitor indicated for:

Acute coronary syndrome

For patients with non-ST-segment elevation ACS [unstable angina (UA)/non-ST-elevation myocardial infarction (NSTEMI)] including patients who are to be managed medically and those who are to be managed with coronary revascularization, Plavix has been shown to decrease the rate of a combined endpoint of cardiovascular death, myocardial infarction (MI), or stroke as well as the rate of a combined endpoint of cardiovascular death, MI, stroke, or refractory ischemia.

For patients with ST-elevation myocardial infarction (STEMI), Plavix has been shown to reduce the rate of death from any cause and the rate of a combined endpoint of death, re-infarction, or stroke. The benefit for patients who undergo primary PCI is unknown.

 

Recent myocardial infarction (MI), recent stroke, or established peripheral arterial disease. Plavix has been shown to reduce the combined endpoint of new ischemic stroke (fatal or not), new MI (fatal or not), and other  vascular death.

Cozaar ®        (Losartan)           MSD

As with all angiotensin II type 1 receptor (AT1) antagonists, losartan is indicated for the treatment of hypertension. It may also delay progression of diabetic nephropaty, and is also indicated for the reduction of renal disease progression in patients with type 2 diabetes, hypertension and microalbuminuria (>30 mg/24 hours) or proteinuria (>900 mg/24 hours).

Hypertension

Cozaar is indicated for the treatment of hypertension. It may be used alone or in combination with

other antihypertensive agents, including diuretics.

Hypertensive Patients with Left Ventricular Hypertrophy

Cozaar is indicated to reduce the risk of stroke in patients with hypertension and left ventricular

hypertrophy, but there is evidence that this benefit does not apply to Black patients.

Nephropathy in Type 2 Diabetic Patients

Cozaar is indicated for the treatment of diabetic nephropathy with an elevated serum creatinine and

proteinuria (urinary albumin to creatinine ratio ¡Ý300 mg/g) in patients with type 2 diabetes and a history of hypertension. In this population, COZAAR reduces the rate of progression of nephropathy as measured by the occurrence of doubling of serum creatinine or end stage renal disease (need for dialysis or renal transplantation) .

Hyzaar ®         (Losartan– Hydrochlorothiazide)       MSD

is used for treating high blood pressure

Hypertension

Hyzaar is indicated for the treatment of hypertension. This fixed dose combination is not indicated

for initial therapy of hypertension, except when the hypertension is severe enough that the value of

achieving prompt blood pressure control exceeds the risk of initiating combination therapy in these

patients.

Hypertensive Patients with Left Ventricular Hypertrophy

Hyzaar is indicated to reduce the risk of stroke in patients with hypertension and left ventricular

hypertrophy, but there is evidence that this benefit does not apply to Black  patients.

Flodil  ®             (Felodipine)    AstraZeneca 

belongs to the group of medicines called calcium-channel blockers.

Flodil is used to treat high blood pressure (hypertension) and to prevent angina (chest pain caused by too little oxygen reaching the heart muscle).

 Logimax ®      (Felodipine-Metoprolol)    AstraZeneca

is a fixed dose, once daily combination of the vascular Selective calcium antagonist, felodipine, and the cardioselective beta-blocker metoprolol for hypertension.

Mono-Tildiem ® (Diltiazem Hcl)           Sanofy-Aventis

Prevention of attacks of stable angina.

Hypertention

Rasilez ® (Aliskiren)                                                 Novartis

is a treatment for high blood pressure, and the first and only approved direct renin inhibitor.

Rasilez HCT® (Aliskiren-Hydrochlorothiazide).      Novartis

 Single-pill combination product.

 Soprol ®            (Bisoprolol)                                       Wyeth

cardioselective beta blockers   

is used in the treatment of:

Angina Pectoris Prophylaxys Heart Failure

High Blood Pressure

Mitral Valve Prolapse

Premature Ventricular Depolarizations

Supraventricular Tachycardia

Wytens ®         (Bisoprolol -Hydroclorothiazide)         Wyeth

is used in the treatment of: High Blood Pressure

Trinipatch ® (Nitroglycerin )                                           Sanofi-Aventis

may be employed as a prophylactic means only against angina pectoris. Due to its slow action, this medicine is not suitable for use in the case of an acute attack.

Zestril ®                  (Lisinopril)                                        AstraZeneca

angiotensin converting enzyme inhibitors(ACE-I)

 is indicated for the treatment of :

 Hypertension.

Heart Failure

Acute Myocardiol Infarction

 Zestoretic® (Lisinopril -Hydrochlorothiazide)              AstraZeneca

  is indicated for the treatment of Hypertension.The fixed dose association are not indicated for initial therapy.

 Dermatology  

  Cetavlon®           (Cetrimide)                      Pierre Fabre Sante

Antiseptics. Used in the treatment of dermatological diseases.

Daivobet ®  (  Calcipotriol-Betametasone Dipropiate )    Leo Pharma

Psoriasis Vulgaris

Mycoster®  (Ciclopirox Olamine)  Pierre Fabre  Dermatologie

is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. It is most useful against Tinea versicolor. 

 Gastrointestinal

Eupantol ®          ( Pantoprazole)                  Nycomed 

Pantoprazole is used to treat erosive esophagitis (damage to the esophagus from stomach acid), and other conditions involving excess stomach acid such as Zollinger-Ellison syndrome . 

Forlax ®                 (Macrogol )                   Beaufour Ipsen

Symptomatic treatment of constipation in adult.

Maalox ®       ( Aluminium Hydroxide and Magnesium Hydroxide)               Sanofi Aventis.

Antacid therapy in gastric and duodenal ulcer, gastritis, heartburn and gastric hyperacidity

Nexium®                 ( Esomeprasole )                                  AstraZeneca

Treatment of Gastroesophageal reflux Disease GERD

Risk Reduction of NSAID-Associated Gastric Ulcer

H.pilory Eradication to Reduce the Risk of Duodenal Ulcer Recurrence

Patologycal Hypersecretory Conditions including Zollinger-Ellisson Syndrome

Gynecology

Cervarix®                                              GlaxoSmithkline

( (Human Papillomavirus vaccine (Types 16, 18) (Recombinant, adjuvanted, adsorbed))

is indicated for the prevention of the following diseases caused by oncogenic human papillomavirus (HPV) types 16 and 18 :

• cervical cancer,

• cervical intraepithelial neoplasia (CIN) grade 2 or worse and adenocarcinoma in situ, and

• cervical intraepithelial neoplasia (CIN) grade 1.

Cervarix is approved for use in females 9 through 25 years of age.

Gardasil ®                                               Sanofy Pasteur MSD

( (Human Papillomavirus vaccine (Types 6,11,16, 18) (Recombinant, adjuvanted, adsorbed)) is a vaccine indicated in girls and women 9 through 26 years of age for the prevention of the following diseases caused by Human Papillomavirus (HPV) types included in the vaccine:

Cervical, vulvar, vaginal, and anal cancer caused by HPV types 16 and 18 Genital warts (condyloma acuminata) caused by HPV types 6 and 11

And the following precancerous or dysplastic lesions caused by HPV types 6, 11, 16, and 18:

recommended. Syncope, sometimes associated with tonic-clonic

Cervical intraepithelial neoplasia (CIN) grade 2/3 and Cervical adenocarcinoma in situ (AIS)

Cervical intraepithelial neoplasia (CIN) grade 1

Vulvar intraepithelial neoplasia (VIN) grade 2 and grade 3

Vaginal intraepithelial neoplasia (VaIN) grade 2 and grade 3

Anal intraepithelial neoplasia (AIN) grades 1, 2, and 3

GARDASIL is indicated in boys and men 9 through 26 years of age for the prevention of the following diseases caused by HPV types included in the vaccine:

Anal cancer caused by HPV types 16 and 18

Genital warts (condyloma acuminata) caused by HPV types 6 and 11

And the following precancerous or dysplastic lesions caused by HPV types 6, 11, 16, and 18:

Anal intraepithelial neoplasia (AIN) grades 1, 2, and 3. (1)

Oral hormonal contraception             Wyeth

Minesse ®             ( G e s t o d e n e 6 0 µ g / E t h i n y l e s t r a d i o l 1 5 µ g )

Minulet ®           (Gestodene 75 micrograms/ Ethinylestradiol 30 micrograms )

Harmonet ®         (Gestodene 75 mcg, Ethinylestradiol 20 mcg)

Tri-Minulet® (Ethinylestradiol 30 microgram s, gestodene 50 micrograms)

Viagra ®                (Sildenafil)                            Pfizer

is used for the treatment of erectile dysfunction.

Infections

Clamoxyl ®               ( Amoxicillin - Clavulanic Acid)    GSK

The product is ideally suitable for the immediate treatment of acute and severe infections including:

Topical infections: Wounds, skin infections.

Respiratory infections involving upper and lower respiratory tract.

Urogenital tract infections.

Gastro-intestinal infections.

Dynabac®        (Dirithromycin)      Allmirall SAS

a member of the macrolide group of antibiotics, has received approval for expanded coverage within certain indications, including the treatment of acute bacterial exacerbations of chronic bronchitis and uncomplicated skin and skin structure infections.

Josacine ®                (Josamycin )                              Sanofy

It is an antibiotic belonging to the macrolides, which is used to treat various diseases infectious in nature, mainly when they relate to the throat, lungs, sinuses, bronchial tract and skin.

Zithromax ®            (Azithromycin)                          Pfizer

is indicated for the treatment of patients with mild to moderate infections (pneumonia)

 Metabolism

Renutryl Booster ®                         Nestlé 

 Nutritional support of the cancer patient.  

Pain/Inflammation

Brexin ®                 (Piroxicam-β-cyclodextrin )

                                                     Pierre Fabre Sante 

Treatment of pain & inflammatory conditions in rheumatic  diseases eg RA,OA; RA, OA musculoskeletal disorders eg tendinitis, bursitis,

post-traumatic pain; post-op pain; primary

dysmenorrhoea.

Ketum Gel ®                  (Ketoprofen )                   Menari

Joint, tendon, ligament or muscular pain, inflammation or injury (arthritis, periarthritis, arthrosynovitis,

tendinitis, bursitis, contusions, sprains, luxations, lesions of the meniscus, stiff neck, backache).

Spasfon ®                  (Phloroglucinol)                               Cephalon

antispasmodic prescribed for all kinds of intestinal, rectal, vaginal spasmodic pain - often in conjunction with other medication .

Voltaren Gel ^{® (Diclofenac)}                                     Novartis

is a nonsteroidal anti-inflammatory drug (NSAID) used for the relief of joint pain of osteoarthritis in the knees, ankles, feet, elbows, wrists, and hands. Voltaren Gel has not been studied for use on the spine, hip or shoulder.

Respiratory

Exomuc ®     (N-Acetylcisteine)          Bouchara Recordati

Oral mucolytic

Treatment of bronchial secretion disorders in acute bronchial infections eg acute bronchitis, acute episodes of chronic bronchopneumopathies

Rhinocort ®     (Budesonide)                AstraZeneca

Allergic rhinitis (Hayfever)

Nasal Polyps

Claritin®      (Loratadine)                    Schering Plough

is indicated for the relief of nasal and non-nasal symptoms of seasonal allergic rhinitis and for the treatment of chronic idiopathic urticaria in patients 2 years of age or older.

Zyrtec®           (Cetirizine)                     UCB

Seasonal Allergic Rhinitis:

Perennial Allergic Rhinitis

Chronic Urticaria  

Xyzal ®      ( Levocetirizine Dihydrochloride)       UCB

Seasonal Allergic Rhinitis, Perennial Allergic Rhinitis, Chronic Idiopathic Urticaria

Vaccines :

Boostrixtetra ®                  Gsk

is indicated for active booster immunization against tetanus, diphtheria, pertussis and polyomielitis. Boostrixtetra is approved for use as a single dose in individuals 10 years of age and older.

Cervarix®                               GlaxoSmithkline

Gardasil ®                              Sanofy Pasteur MSD

NeisVac-C ®                          Baxter

is indicated for the active immunisation of children from 2 months of age, adolescents, and adults for the prevention of invasive disease caused by N. meningitidis serogroup C. The use of NeisVac-C should be determined on the basis of official recommendations.

PARTNERS /PHARMACEUTICAL COMPANIES LINKS

Allmirall Sas

AstraZeneca

Baxter

Beaufour Ipsen

Bouchara Recordati

Cephalon

Chiesi Pharmaceuticals

GlaxoSmithkline

Leo Pharma

Lundbeck  

Menarini

Msd

Nestlé 

Novartis

Nycomed 

Pfizer

Pierre Fabre Dermatologie

Pierre Fabre Sante 

Sanofi-Aventis

Sanofy Pasteur Msd

Sanofy-Synthelabo

Schering Plough

Ucb

Wyeth

Wyeth Pharmaceuticals



Prospects in the Russian pharmaceutical industry 

Russia is the main market in the CIS with good prospects for the coming years. With a population of 145 million, it is the largest pharmaceutical market in Central and Eastern Europe.

• Quadrupled health care spending since 2001
• Allocated nearly $1 billion (30 billion roubles) to develop 14 high-tech medical centers in Russia’s regions including cardiology centers in Astrakhan, Khabarovsk, Krasnoyarsk and Kaliningrad and a neurosurgery center in Tyumen
• Invested in preventative medical services and launched national campaigns to discourage bad habits such as smoking and excessive drinking
• Invested more than $28 million in efforts to combat the spread of infectious diseases throughout the former Soviet Union and $250 billion in malaria and AIDS vaccine development
• Increased domestic production of sophisticated medical technologies, with a JV between GE Healthcare and Meditsinskiye Technologii unveiling its first domestically assembled CT scanner in September
• Decreased infant mortality by a third and increased average life expectancy by three years

Looking Forward

Russia’s pharmaceutical market is forecast to grow to $20 billion in 2010 with more significant growth expected next year

Russia will host the first international conference on promoting healthy lifestyles in Moscow next year